Hemoglobin A2 In Blood

From Anvita Health Wiki

Contents 1 Indications 2 Reference-interval 3 Clinical-significance 4 Increases 5 Decreases 6 Specimen 7 More General Terms 8 Additional Terms 9 References

Indications

• evaluation of hemoglobinopathy

Reference-interval

• 1.5-3.5%

Clinical-significance

• contribution to total hemoglobin increases with defects in hemoglobin beta-chain ( beta-thalassemia)

Increases

• beta thalassemia ( trait: 3.7-7%)
• drug-induced megaloblastic anemia
• hemoglobinopathy (values in excess of 10%)

• hemoglobin C

• hemoglobin SC (50%)

• hemoglobin E
• hemoglobin O

Decreases

• untreated iron deficiency
• erythroleukemia
• hemoglobin H disease
• delta- thalassemia

Specimen

• hemolysate prepared from whole blood ( EDTA, heparin, oxalate)
• stable for 30 days at 4 degrees C

More General Terms

• clinical hematology test

Additional Terms

• hemoglobin A2

References

1. Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 646
2. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995

hemoglobin A2 in blood