Hemagluttination Inhibition Test

From Anvita Health Wiki

Contents 1 Indications 2 Principle 3 Clinical-significance 4 More General Terms 5 Additional Terms 6 References

Indications

• determination of antibodies directed against influenza virus
• assessment of immunity to influenza

Principle

• influenza virus particles contain an envelope protein called hemagglutinin which binds to sialic acid receptors on cells, including erythrocytes
• viruses thus agglutinate RBCs via hemagglutinin binding to RBCs
• antibodies directed against these viruses will inhibit hemagluttination
• hemagluttination inhibition is thus a measure of antibodies direct against hemagluttinating viruses

Clinical-significance

• a titer of 1:40 is associated with a 50% reduction in risk of influenza

More General Terms

• clinical hematology test

Additional Terms

• influenza
• Orthomyxoviridae (influenza virus)

References

1. Influenza hemagglutination inhibition assay [1]

hemagluttination inhibition test (HAI)