Hb Egf

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Laboratory 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

Function

• may be involved in macrophage-mediated cellular proliferation
• mitogenic for fibroblasts & smooth muscle but not endothelial cells
• it is able to bind EGF receptors with higher affinity than EGF itself & is a far more potent mitogenfor smooth muscle cells than EGF
• inducer of increased vascular permeability
• acts as a diphtheria toxin receptor

Structure

• contains 1 EGF-like domain

Compartment

• heparin-binding EGF-like growth factor:

• secreted, extracellular space
• mature HB- EGF is released into the extracellular space & probably binds to a receptor

• proheparin-binding EGF-like growth factor:

• cell membrane; single-pass type 1 membrane protein

Laboratory

• heparin-binding protein in CSF is a marker for bacterial meningitis Expession:
• released from activated neutrophils in severe sepsis

More General Terms

• glycoprotein
• secreted peptide
• growth factor
• membrane protein

Additional Terms

• heparin-binding protein in CSF

Internet Database

Entrez gene: 1839
Kegg: [1]
OMIM: 126150
Prosite: [2]
Prosite: [3]
Prosite: [4]
UniProt: [5]

References

1. UniProt [6]
2. NIEHS-SNPs [7]
3. Ross R The pathogenesis of atherosclerosis Nature 362:801 1993 PMID: [8]

heparin-binding EGF-like growth factor; heparin-binding protein; HB-EGF; HBEGF; diphtheria toxin receptor; DT-R (HBEGF, DTR, DTS, HEGFL)