H2 Receptor

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Pharmacology 5 More General Terms 6 Internet Database 7 References

Function

• H2 subclass of histamine receptors mediates gastric acid secretion
• also appears to regulate gastrointestinal motility & intestinal secretion
• possible role in regulating cell growth & differentiation
• activity is mediated by G proteins which activate adenylyl cyclase ( Gs proteins) &, through a separate G protein-dependent mechanism, the phosphoinositide/ protein kinase C ( PKC) signaling pathway ( putative)

Structure

• belongs to the G-protein coupled receptor 1 family
• membrane pocket formed by 7 transmembrane regions forms ligand binding site & provides for interaction of receptor with G protein

Compartment

• cell membrane

Pharmacology

• histamine-H2-receptor antagonists are used in treatment of gastirc acid disorders, i.e. dyspepsia, peptic ulcer disease, gastritis, GERD

More General Terms

• histamine receptor
• glycoprotein

Internet Database

Kegg: [1]
OMIM: 142703
Prosite: [2]
Prosite: [3]
UniProt: [4]

References

1. UniProt [5]
2. Wikipedia; Note: H2 receptor entry [6]

histamine H2 receptor; H2R; gastric receptor I (HRH2)