Glycoprotein Endo Alpha 1 2 Mannosidase

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• undergoes proteolytic cleavage in the C-terminal region
• hydrolysis of the terminal alpha-D-glucosyl-(1,3)-D-mannosyl unit from the GlcMan(9)( GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane
  

• Kinetic parameters:

• Optimum pH is 6.2
• Optimum temperature 37 degrees C

Structure

• belongs to the glycosyl hydrolase 99 family

Compartment

• Golgi membrane

Expression

• highly expressed in the liver & kidney
• expressed at lower levels in muscle, pancreas, heart, placenta, lung & brain

More General Terms

• alpha-mannosidase (MANA)
• membrane protein

Internet Database

UniProt: [1]

References

UniProt [2]

glycoprotein endo-alpha-1,2-mannosidase (mandaselin, hEndo, MANEA)