Glycine Receptor

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 Pathology 7 More General Terms 8 Additional Terms 9 Internet Database 10 References

Function

• neurotransmitter-gated ion channel
• binding of glycine to its receptor increases the chloride conductance, thus produces hyperpolarization (inhibition of neuronal firing)
• associates with 93 kD cytoplasmic protein

Structure

• pentamer composed of alpha & beta subunits

Compartment

• membrane

Alternative-splicing

• named isoforms=2

Expression

• widely distributed throughout central nervous system

Pathology

• alpha subunit binds strychnine

More General Terms

• cell surface receptor
• Cl- channel
• multisubunit protein

Additional Terms

• glycine

Internet Database

Prosite: [1]

References

1. Grenningloh G, Pribilla I, Prior P, Multhaup G, Beyreuther K, Taleb O, Betz H. Cloning and expression of the 58 kd beta subunit of the inhibitory glycine receptor. Neuron. 1990 Jun;4(6):963-70. PMID: [PubMed - indexed for MEDLINE&dopt=Abstract]
2. Grenningloh G, Schmieden V, Schofield PR, Seeburg PH, Siddique T, Mohandas TK, Becker CM, Betz H. Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 1990 Mar;9(3):771-6. PMID: [2]
3. Barnard EA. Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci. 1992 Oct;17(10):368-74. Review. PMID: [3]

glycine receptor