Glutamate Receptor Zeta 1
From Anvita Health Wiki
Contents |
Function
- NMDA receptor subunit
- high Ca+2 permeability
- voltage-dependent sensitivity to Mg+2
- mediated by glycine
- plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition & learning
- mediates neuronal functions in glutamate neurotransmission
- involved in the cell surface targeting of NMDA receptors ( putative)
- forms heteromeric channel of:
- disulfide-linked
- found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B & PPP2CB
- interacts with DLG4 & MPDZ ( putative)
- NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC
- dephosphorylated on Ser-897 probably by protein phosphatase 2A ( PPP2CB)
- phosphorylated state is influenced by the formation of the NMDAR- PPP2CB complex & the NMDAR channel activity ( putative)
Structure
- belongs to the glutamate-gated ion channel (TC 1.A.10) family
- disulfide-linked
Compartment
- cell membrane
- cell junction, synapse, postsynaptic cell membrane ( putative)
- postsynaptic density ( putative)
- enriched in post-synaptic plasma membrane & post-synaptic densities
Alternative-splicing
- named isoforms=5
More General Terms
Internet Database
Kegg: [1]
OMIM: 138249
UniProt: [2]
Entrez gene: 2902
References
- Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, et al. Molecular diversity of the NMDA receptor channel. Nature. 1992 Jul 2;358(6381):36-41. PMID: [3]
- Hynd MR, Scott HL, Dodd PR. Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease. J Neurochem. 2004 Apr;89(1):240-7. PMID: [4]
- UniProt [5]
- Wikipedia; Note: NMDA receptor entry [6]
