Glutamate Receptor Ionotropic Ampa 4
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Contents |
Function
- ionotropic glutamate receptor
- binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, & thereby converts the chemical signal to an electrical impulse
- the receptor then desensitizes rapidly & enters a transient inactive state, characterized by the presence of bound agonist
- palmitoylated
- depalmitoylated upon glutamate stimulation
- Cys-611 palmitoylation leads to Golgi retention & decreased cell surface expression
- in contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation- dependent endocytosis ( putative)
Structure
- homotetramer or heterotetramer of pore-forming glutamate receptor subunits
- tetramers may be formed by the dimerization of dimers
- belongs to the glutamate-gated ion channel (TC 1.A.10) family
Compartment
More General Terms
Internet Database
OMIM: 138246
UniProt: [1]
Entrez gene: 2893
References
UniProt [2]
