Glucose 6 Phosphatase

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Pathology 4 More General Terms 5 Additional Terms 6 Internet Database 7 References

Function

• may act both as a hydrolase & a translocase
• key enzyme in homeostatic regulation of blood glucose levels
• gluconeogenesis & glycogenolysis; last step
  

• D-glucose 6-phosphate + H2O <--> D-glucose + phosphate

Compartment

• endoplasmic reticulum membrane

Pathology

• defects in G6PC are the cause of glycogen storage disease type 1A

More General Terms

• phosphomonoesterase
• gluconeogenic enzyme
• glycoprotein
• membrane protein

Additional Terms

• gluconeogenesis
• glycogen storage disease type-I (von Gierke type glycogen storage disease)

Internet Database

OMIM: 232200
UniProt: [1]

References

1. UniProt [2]
2. GeneReviews [3]

glucose-6-phosphatase (G6Pase, G-6-Pase, G6PC, G6PT)