Glucosamine 6 Phosphate N Acetyltransferase

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Additional Terms 6 Internet Database 7 References

Function

• nucleotide- sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2
  

• acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate
• Kinetic parameters:

• KM=26 uM for acetyl-coenzyme A
• KM=97 uM for glucosamine-6-phosphate

Structure

• homodimer
• belongs to the acetyltransferase family, GNA1 subfamily
• contains 1 N-acetyltransferase domain

Compartment

• Golgi membrane
• peripheral membrane protein
• endosome membrane

More General Terms

• acetyltransferase
• membrane protein

Additional Terms

• CDC42 homolog; cell division control protein 42 homolog; G25K GTP-binding protein (CDC42)

Internet Database

Entrez gene: 64841
Kegg: [1]
Prosite: [2]
UniProt: [3]

References

UniProt [4]

glucosamine 6-phosphate N-acetyltransferase; phosphoglucosamine acetylase; phosphoglucosamine transacetylase (GNPNAT1, GNA1)