Glucarpidase

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Pharmacokinetics 4 Adverse-effects 5 Mechanism-of-action 6 More General Terms 7 References

Indications

• treatment of methotrexate toxicity due to renal failure

Dosage

• intravenous administration

Pharmacokinetics

• methotrexate levels fall below critical levels in 15 minutes
• 95% of methotrexate is eliminated

Adverse-effects

• hypotension
• headache
• nausea/vomiting
• flushing
• paraesthesias

Mechanism-of-action

• rapidly reduces methotrexate levels via metabolism to a form that can be eliminated in patient

More General Terms

• antidote

References

1. FDA NEWS RELEASE: Jan. 17, 2012 FDA approves Voraxaze to treat patients with toxic methotrexate levels [1]

glucarpidase (Voraxaze)