Gilles De La Tourette's Syndrome

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Contents 1 Introduction 2 Etiology 3 Epidemiology 4 Genetics 5 Clinical-manifestations 6 Management 7 More General Terms 8 Additional Terms 9 Internet Database 10 References

Introduction

• (also see NINDS Tourette Syndrome Information Page)

Etiology

• unknown

Epidemiology

• rare
• affected individuals may be of any level of intelligence

Genetics

• associated with defects in IMMP2L gene
• associated with defectes in SLITRK1 gene

Clinical-manifestations

• widespread motor & vocal tics
• behavorial abnormalities

• coprolalia (uncommon)

• onset in childhood
• frequently persists into early adulthood

Management

• treatment of motor tics with:

• haloperidol ( Haldol)
• clonidine
• clonazepam
• chlorpromazine

More General Terms

• chronic neurologic disease
• syndrome

Additional Terms

• chlorpromazine (Thorazine, Ormazine, Propaphenin, Sonazine, Chloractil)
• clonazepam (Klonopin)
• clonidine (Catapres)
• coprolalia (coprophrasia)
• haloperidol (Haldol, Halperon, Aloperidol, Halomonth)

Internet Database

OMIM: 137580

References

1. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
2. DSM-IV
3. NIH Institute & Center Resources [1]
4. NINDS Tourette Syndrome Information Page [2]

Gilles de la Tourette's syndrome