Gdc 0449

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Mechanism-of-action 4 More General Terms 5 References

Indications

• rare cases of locally invasive or metastatic basal cell carcinoma (experimental) [1]

Dosage

• 150-540 mg PO QD

Mechanism-of-action

• interferes with hedgehog/ gli pathway

More General Terms

• antineoplastic agent (chemotherapeutic agent)

References

1. Von Hoff DD et al Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009 Sep 2 <PubMed> PMID: [1] <Internet> [2]
   - Dlugosz AA and Talpaz M. Following the hedgehog to new cancer therapies. N Engl J Med 2009 Sep 2 <PubMed> PMID: [3] <Internet> [4]

GDC-0449