Gallbladder Cancer
From Anvita Health Wiki
Contents |
Etiology
- (associated factors)
- genetic predisposition
- gallstones
- gallbladder polyps
- calcification of the gallbladder wall (porcelain gallbladder)
- bile composition
- environmental carcinogens
- infections ( Salmonella typhi)
- drugs
Epidemiology
- greatest incidence in patients > 65 years of age
- female/male ratio is 3/1
Clinical-manifestations
- may resemble biliary colic or cholecystitis
- abdominal pain is the most common initial complaint
- pattern of pain is variable
- nausea/vomiting
- anorexia
- weight loss
- jaundice may occur
- a palpable mass may be felt
- ascites may occur
Laboratory
-
- alkaline phosphatase may be elevated
- bilirubin may be elevated
- CEA may be elevated, but is not diagnostic
- CA 19-9 may be elevated, but is not diagnostic
Radiology
-
- thickening of gallbladder wall
- gallbladder mass
- calcification of gallbladder (porcelain gallbladder)
Complications
Management
-
- only intervention that can result in a cure
- 80% of patients have unresectable disease at the time of cholecystecotomy
- chemotherapy does not improve survival
- radiation does not significantly improve survival
More General Terms
Additional Terms
References
- UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
- Gallbladder Cancer: NIH Institute and Center Resources [1]
- National Guideline Clearinghouse The role of gemcitabine in the treatment of cholangiocarcinoma and gallbladder cancer. (Program in Evidence-based Care) ngc-guideline: [2]
