Gaba B Receptor 2
From Anvita Health Wiki
Contents |
Function
- receptor for GABA
- activity is mediated by G-proteins that
- inhibit adenylyl cyclase activity
- stimulate phospholipase A2
- activate K+ channels
- inactivate voltage-dependent Ca+2-channels
- modulate inositol phospholipid hydrolysis
- role in fine-tuning of inhibitory synaptic transmission
- pre-synaptic GABA-B-R inhibits neurotransmitter release by down-regulating high- voltage activated Ca+2 channels
- postsynaptic GABA-B-R decreases neuronal excitability by activating a prominent inwardly rectifying K+ channel (Kir conductance) that underlies the late inhibitory postsynaptic potentials
- implicated in:
- synaptic inhibition
- hippocampal long-term potentiation
- slow wave sleep
- muscle relaxation
- antinociception
Structure
- alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1
- belongs to the G-protein coupled receptor 3 family GABA-B receptor subfamily
Compartment
- cell membrane; multi-pass membrane protein
- cell junction, synapse, postsynaptic cell membrane
- coexpression of GABA-B-R1 & GABA-B-R2 appears to be requeired for maturation & transport of GABA-B-R1 to the plasma membrane
Expression
- highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital & temporal lobe, occipital pole & cerebellum
- lesse expression in corpus callosum, caudate nucleus, spinal cord, amygdala & medulla
- weakly expressed in heart, testis & skeletal muscle
More General Terms
Internet Database
Entrez gene: 9568
Kegg: [1]
OMIM: 607340
Prosite: [2]
Prosite: [3]
Prosite: [4]
Prosite: [5]
UniProt: [6]
References
UniProt [7]
