G Protein Coupled Receptor Kinase 6

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• specifically phosphorylates activated forms of G protein-coupled receptors

* ATP + [G-protein-coupled receptor]  
*                 <--> 
* ADP + [G-protein-coupled receptor] phosphate

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
• contains 1 AGC- kinase C-terminal domain
• contains 1 protein kinase domain
• contains 1 RGS domain
• uncertain whether palmitoylation is on Cys-561 &/or Cys-562 &/or Cys-565

Compartment

• membrane; lipid-anchor

Alternative-splicing

• named isoforms=2

Expression

• widely expressed

More General Terms

• G protein-coupled receptor kinase
• phosphoprotein
• membrane protein

Internet Database

OMIM: 600869
Prosite: [1]
Prosite: [2]
Prosite: [3]
Prosite: [4]
UniProt: [5]
Entrez gene: 2870

References

1. UniProt [6]
2. OMIM [7]

G protein-coupled receptor kinase-6 (GRK6, GPRK6)