G Protein Coupled Receptor Gpr64

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Additional Terms 8 Internet Database 9 References

Function

• could be involved in a signal transduction pathway controlling epididymal function & male fertility
• proteolytically cleaved into 2 subunits, an extracellular subunit & a seven- transmembrane subunit ( putative)
• forms a heterodimer, consisting of a large extracellular region linked to a seven- transmembrane moiety (probable)

Structure

• belongs to the G-protein coupled receptor 2 family LN-TM7 subfamily
• contains 1 GPS domain

Compartment

• cell membrane; multi-pass membrane protein

Alternative-splicing

• named isoforms=9

Expression

• epididymis specific
• both subunits are associated with apical membranes of efferent ductule & proximal epididymal duct epithelia

More General Terms

• G-protein coupled receptor; serpentine receptor
• phosphoprotein

Additional Terms

• epididymis

Internet Database

Entrez gene: 10149
Kegg: [1]
OMIM: 300572
Prosite: [2]
Prosite: [3]
Prosite: [4]
UniProt: [5]

References

1. OMIM [6]
2. UniProt [7]

G-protein coupled receptor 64; human epididymis-specific protein 6; He6 (GPR64, HE6, TM7LN2)