Fringe Protein

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Contents 1 More Specific Terms 2 Introduction 3 Function 4 Comparative-biology 5 More General Terms 6 References

More Specific Terms

• lunatic fringe homolog or beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
• manic fringe homolog (MFNG, beta-1,3-N-acetylglucosaminyltransferase manic fringe)
• radical fringe homolog or beta-1,3-N-acetylglucosaminyltransferase radical fringe

Introduction

• family of proteins which participate in the formation of boundaries between groups of cells during development.

Function

• Fringe proteins have fucose-specific beta 1,3-N-acetylglucos-aminyltransferase activity that catalyzes elongation of O-linked fucose on EGF repeats of Notch, which modulates Notch signaling.
• Fringe proteins can positively and negatively modulate the ability of Notch ligands to activate Notch receptors
• there are functional differences between various fringes in their ability to modulate different Notch ligand binding to Notch receptors
• Fringe beta 1,3-N- acetylglucosaminyltransferase activity is necessary but not sufficient to inhibit jagged 1 protein induced Notch signalling
• beta-4- galactosyltransferase-1 is also required [2]

Comparative-biology

• originally named Drosophila protein; 3 mammalian homologs identified: lunatic fringe, radical fringe & manic fringe

More General Terms

• glycosyltransferase
• membrane protein

References

1. Shimizu et al. J Biol Chem 276: 25753-8, 2001.
2. Chen et al. PNAS 98:13716-21, 2001

fringe homolog protein