Fresh Frozen Plasma

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 More General Terms 5 Additional Terms 6 References

Introduction

• A unit of fresh frozen plasma is obtained from centrifugation of 500 mL of whole blood. 200 mL of plasma is separated from 300 mL of packed red blood cells & stored frozen for up to 1 year.

Indications

• treatment of coagulation abnormalities secondary to multiple clotting factor deficiencies

• liver disease ( INR > 1.5)
• vitamin K deficiency
• massive transfusion
• disseminated intravascular coagulation ( DIC)

• treatment of thrombotic thrombocytopenic purpura ( TTP) in association with plasmapheresis
• for correction of specific clotting factor deficiencies

• prothrombin deficiency
• factor V deficiency
• factor VII deficiency
• factor IX deficiency ( hemophilia B, Christmas disease)
• factor XI deficiency

• correction of coagulation inhibitor deficiencies

• antithrombin III, protein C or protein S

• correction of warfarin therapy when reveral by vitamin K is not feasible because of time constraints
• infants with protein-losing enteropathy

Contraindications

• specific factor deficiencies for which the isolated factor is available as a single component

• factor VIII deficiency
• factor IX deficiency
• fibrinogen deficiency

• as a simple volume expander Transfusion:

• 10 mL/kg or 1 unit/20 kg of ideal body weight

More General Terms

• transfusion component

Additional Terms

• ideal body weight (IBW)
• plasma

References

1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 613-614
2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
3. Fresh Frozen Plasma: Indications and Risks NIH Consensus Statement [1]
4. National Guideline Clearinghouse Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant. British Committee for Standards in Haematology ngc-guideline: [2]

fresh frozen plasma