Fosinopril

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Pharmacokinetics 5 Adverse-effects 6 Drug-interactions 7 Mechanism-of-action 8 More General Terms 9 Internet Database 10 References

Introduction

• Tradename: Monopril.

Indications

• hypertension
• heart failure

Dosage

• HTN: start 10 mg PO QD, max 80 mg/day
• CHF: start 5-10 mg QD; max 40 mg QD

• Tabs: 10, 20 mg.

Pharmacokinetics

• fosinopril is about 99% bound to plasma proteins
• metabolized in the liver to an active metabolite
• elimination 1/2life is about 12 hours with normal renal function
• 50% of the drug is eliminated by the liver, 50% in the urine
• no dosage adjustments needed in patients with renal insufficiency
  

• elimination via liver
• elimination via kidney

Adverse-effects

• dry, non-productive cough
• rash
• taste disturbances
• worsening renal failure
• angioedema (rare)
  
• drug adverse effects of ACE inhibitors

Drug-interactions

• NSAIDs reduce may reduce hypotensive effect
• phenothiazines increase effects of ACE inhibitors
• allopurinol increases risk of hypersensitivity reactions
• lithium & digoxin levels are increased by fosinopril
• K+ salts & K+ sparing diuretics: increased risk of hyperkalemia
  
• drug interaction(s) of renin-angiotensin inhibitors with trimethoprim-sulfamethoxazole
• drug interaction(s) of lithium carbonate with ACE inhibitors
• drug interaction(s) of ACE inhibitors with aliskiren
• drug interaction(s) of ACE inhibitors with angiotensin II receptor antagonists
• drug interaction(s) of potassium chloride with ACE inhibitors
• drug interaction(s) of spironolactone with ACE inhibitors
• drug interaction(s) of diuretics with ACE inhibitors
• drug interaction(s) of beta blockers with ACE inhibitors
• drug interaction(s) of NSAIDs with ACE inhibitors
• drug interaction(s) of ACE inhibitors, angiotensin II receptor antagonists & beta-blockers
• drug interaction(s) of NSAIDs, diuretics & ACE inhibitors

Mechanism-of-action

• phosphorous-containing ACE inhibitor (prodrug)

More General Terms

• angiotensin-converting enzyme [ACE] inhibitor

Internet Database

PubChem: 55891
PubChem: 55890
PubChem: 3419

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 Department of Veterans Affairs, VA National Formulary
   - non formulary drug request

fosinopril (Monopril)