Forkhead Box A

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Introduction 3 Function 4 More General Terms 5 References

More Specific Terms

• forkhead box protein A1; hepatocyte nuclear factor 3-alpha; HNF-3A (FOXA1)
• forkhead box protein A2; hepatocyte nuclear factor 3-beta; HNF-3B (FOXA2)

Introduction

• The forkhead box A family of transription factors are human homologous of PHA-4 of C elegans, linked to the longevity effects of calorie restriction in worms.

Function

• roles in development
• regulation of glucagon production & glucose homeostasis in adults, especially in response to fasting

More General Terms

• biochemistry

References

- Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature. 2007 May 2; [Epub ahead of print] PMID: [1] forkhead box A (FOXA)