Fodrin

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 More General Terms 4 References

Function

• seems to be involved in secretion
• interacts with calmodulin (Ca+2-dependent)
• Ca+2-dependent movement of the cytoskeleton at the membrane ( putative)
• phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro ( putative)
• like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers

Compartment

• cytoplasm, cytoskeleton
• cell membrane
• peripheral membrane protein; cytoplasmic side ( putative)

More General Terms

• membrane protein
• cytoskeletal protein
• calmodulin binding protein
• PEST protein
• multisubunit protein

References

- Andrews BS. Is the WKS motif the tissue-factor binding site for coagulation factor VII? Trends Biochem Sci. 1991 Jan;16(1):31-6. Review. PMID: [1] fodrin (non erythrocytic spectrin)