Flutamide

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 Dosage 5 Pharmacokinetics 6 Monitor 7 Adverse-effects 8 More General Terms 9 Additional Terms 10 Internet Database 11 References

Introduction

• Tradename: Eulexin.

Indications

• used in combination with LHRH agonist for treatment of metastatic prostate cancer
• hair growth restoration ?

Contraindications

• Pregnancy category X
• significant liver disease
  

• pregnancy category = x

Dosage

• Capsule: 125 mg

Pharmacokinetics

• Not eliminated by hemodialysis
  

Monitor

• serum ALT & serum AST baseline, monthly for 4 months, then periodically (every 6 months) [2,3]; discontinue if serum AST or serum ALT > 3x upper limit of normal despite recheck

Adverse-effects

• common (> 10%)

• impotence, nausea/vomiting, hot flashes, diarrhea

• less common (1-10%)

• anorexia, gynecomastia, numbness in extremities

• uncommon (< 1%)

• hepatitis, hypertension, edema, drowsiness, nervousness, confusion

More General Terms

• receptor antagonist
• antineoplastic agent (chemotherapeutic agent)

Additional Terms

• prostate carcinoma (prostate cancer)

Internet Database

PubChem: 3397

References

1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
2. Anvita Health guideline :id 1656
3. Prescriber's Letter 17(7): 2010 Recommended Lab Monitoring for Common Medications Liver Function Test Scheduling Detail-Document#: [1] (subscription needed) [2]

flutamide (Eulexin, Niftholide)