Flavoprotein Monooxygenase 4

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Polymorphism 6 More General Terms 7 Internet Database 8 References

Function

• role in oxidative metabolism of a variety of xenobiotics such as drugs & pesticides

* N,N-dimethylaniline + NADPH + O2  
*          <-->  
* N,N- dimethylaniline N-oxide + NADP+ + H2O

• Cofactor: FAD

Structure

• belongs to the FMO family

Compartment

• microsome membrane
• endoplasmic reticulum membrane

Expression

• liver

Polymorphism

• polymorphism in FMO4 associated with fish-odor syndrome

More General Terms

• flavoprotein mixed function oxidase
• membrane protein

Internet Database

UniProt: [1]
Entrez gene: 2329
Kegg: [2]
OMIM: 136131

References

1. UniProt [3]
2. NIEHS-SNPs [4]

flavoprotein monooxygenase 4; dimethylaniline oxidase 4; dimethylaniline monooxygenase [N-oxide forming] 4 (FMO4)