Flavopiridol

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Adverse-effects 4 Mechanism-of-action 5 More General Terms 6 References

Indications

• relapsed chronic lymphocytic leukemia ( CLL)

Dosage

• bolus flavopiridol followed by 4-hour flavopiridol infusion weekly for 3 weeks (28-day cycle)
• prophylactic dexamethasone with each flavopiridol dose
• rasburicase before the first two doses of flavopiridol to prevent tumor lysis syndrome
• pegfilgrastim with each cycle
• antimicrobial prophylaxis throughout course of treatment

Adverse-effects

• most common: (all >90%)

• neutropenia
• diarrhea
• fatigue
• abnormal liver function tests

• less common

• tumor lysis syndrome (44%),
• cytokine release syndrome (42%)
• infections despite prophylactic antibiotics (25%)

Mechanism-of-action

• cyclin-dependent kinase inhibitor

More General Terms

• antineoplastic agent (chemotherapeutic agent)
• enzyme inhibitor

References

- Lin TS et al Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. J Clin Oncol. 2009 Dec 10;27(35):6012-8. Epub 2009 Oct 13. <PubMed> PMID: [1] <Internet> [2] flavopiridol