Fibronectin Type Iii & Spry Domain Containing Protein 1

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Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

Function

• may be involved in microtubule organization & stabilization
• oligomerization is required for binding to microtubules

Structure

• B30.2 box contains a microtubule- binding site
• contains 1 B30.2/SPRY domain
• contains 1 COS domain
• contains 1 fibronectin F3 module

Compartment

• centrosome, nucleus, cytoplasm
• cell-cycle-dependent association with the centrosome
• colocalizes with a subpopulation of microtubules
• does not associate with microtubules during mitosis but reassociates with microtubules during cytokinesis
• localizes to the central portions of a small subset of microtubules in interphase cells & a subpopulation of microtubules in the cleavage furrow
• not present in the mitotic spindle

Expression

• highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe & putamen
• lower expression in spinal cord

More General Terms

• uncharacterized protein

Additional Terms

• fibronectin type III & SPRY domain-containing protein

Internet Database

Kegg: [1]
UniProt: [2]

References

UniProt [3]

fibronectin type III & SPRY domain-containing protein 1 (microtubule-associated protein GLFND, MID1-related protein 1, FSD1, GLFND, MIR1, VLP27)