Fibrate

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Introduction 3 Indications 4 Monitor 5 Mechanism-of-action 6 Clinical-trials 7 More General Terms 8 Additional Terms 9 References

More Specific Terms

• clofibrate (Atromid-S)
• fenofibrate (Antara, TriCor, Triglide, Lofibra, Proctofene, Trilipix)
• gemfibrozil (Lopid)

Introduction

• Also see individual agent.

Indications

• used largely for treatment of hypertriglyceridemia
• in combination with bile acid sequestrant resin for familial combined hyperlipidemia

Monitor

• liver function tests
• serum triglycerides every 2 months [2]
• renal function during 1st few months [5]
  
• monitor with fibrates

Mechanism-of-action

• 35% reduction in triglycerides
• 10% reduction in LDL cholesterol
• 10% increase in HDL cholesterol

Clinical-trials

• appears to lower the risk for coronary events (benefit modest but may be clinically significant for high risk patients) [3]
• no benefit in terms of stroke, mortality, or heart failure
• lack of evidence to support adjunct to statin therapy [4]

More General Terms

• anti-hyperlipidemic agent
• peroxisome proliferator

Additional Terms

• bile acid sequestrant

References

1. Principles of Geriatric Medicine & Gerontology, 4th ed, Hazzard et al (eds), McGraw-Hill, 1999
2. Anvita Health guideline :id 1539
3. Jun M et al, Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis The Lancet, Early Online Publication, 11 May 2010 PMID: [1] doi:10.1016/S0140-6736(10)60656-3 [2]
4. Jackevicius CA et al. Use of fibrates in the United States and Canada. JAMA 2011 Mar 23/30; 305:1217 PMID: [3]
5. Zhao YY et al New Fibrate Use and Acute Renal Outcomes in Elderly Adults A Population-Based Study Annals of Internal Medicine 2012 156(8):560-569 <PubMed> PMID: [4] <Internet> [5]

fibrate