Fgfr1 Oncogene Partner 2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 Pathology 7 More General Terms 8 Internet Database 9 References

Function

• may be involved in wound healing pathway

Structure

• belongs to the SIKE family

Compartment

• cytoplasm ( putative)

Alternative-splicing

• named isoforms=3

Expression

• expressed in bone marrow, spleen & thymus

Pathology

• chromosomal insertion ins(12;8)(p11;p11p22) involving FGFR1OP2 with FGFR1 may be a cause of stem cell myeloproliferative disorder ( MPD)
• fusion protein FGFR1OP2- FGFR1 may exhibit constitutive kinase activity & be responsible for the transforming activity

More General Terms

• uncharacterized protein

Internet Database

OMIM: 608858
UniProt: [1]

References

UniProt [2]

FGFR1 oncogene partner 2 (FGFR1OP2)