Fenoprofen

From Anvita Health Wiki

Contents 1 Introduction 2 Dosage 3 Pharmacokinetics 4 Adverse-effects 5 Drug-interactions 6 Laboratory 7 More General Terms 8 Internet Database 9 References

Introduction

• Tradename: Nalfon.

Dosage

• 200-600 mg PO TID/ QID, max 3200 mg/day

• Tabs: 200, 300, 600 mg.

Pharmacokinetics

• food decreases rate & extent of absorption
• metabolized in liver to form 4-hydroxyfenoprofen glucuronide & fenoprofen glucuronide
  

• elimination via liver
• 1/2life = 2.5-3 hours
• protein binding = 99 %
• elimination by hemodialysis = -
• elimination by peritoneal dialysis = -

Adverse-effects

• gastrointestinal disturbance
• rash
• tinnitus
• confusion
• anorexia
• leukopenia & thrombocytopenia (rare)
• nephrotoxicity (uncommon)
• hepatotoxicity (uncommon)
  
• drug adverse effects of NSAIDs

Drug-interactions

• coadministration of aspirin decreases fenoprofen concentrations
• probenecid may increase fenoprofen concentration
• fenoprofen may increase plasma levels of:

• digoxin
• Li+
• methotrexate
  

• drug interaction(s) of lithium carbonate with NSAIDs
• drug interaction(s) of NSAIDs with SSRIs
• drug interaction(s) of aspirin with NSAIDs
• drug interaction(s) of NSAIDs with beta blockers
• drug interaction(s) of NSAIDs with ARBs
• drug interaction(s) of NSAIDs with ACE inhibitors
• drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
• drug interaction(s) of NSAIDs, diuretics & ACE inhibitors
• drug interaction(s) of NSAIDs & loop diuretics
• drug interaction(s) of NSAIDs & aspirin

Laboratory

• specimen: serum, plasma ( heparin, EDTA)
• methods: GLC, HPLC

More General Terms

• non-steroidal anti-inflammatory agent (NSAID)
• peroxisome proliferator

Internet Database

PubChem: 3342
PubChem: 60897

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelpha 1995

fenoprofen (Nalfon)