Fc Receptor Like Protein 6

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 Pathology 7 More General Terms 8 Internet Database 9 References

Function

• interacts with PTPN11
• phosphorylated on Tyr, inducing association with PTPN11

Structure

• contains 3 Ig-like C2-type domain ( immunoglobulin-like)
• contains 1 ITIM motif, phosphorylated ITIM motif has role in PTPN11 binding

Compartment

• membrane

Alternative-splicing

• named isoforms=4

Expression

• expressed by cytolytic cells including NK cells, effector & effector- memory CD8+ T-cells

Pathology

• expression among T-cells is greatly expanded in HIV-1 infected individuals, & includes not only effector & effector- memory CD8+ T-cells but also populations of CD4+ T-cells

More General Terms

• immunoglobulin superfamily protein
• phosphoprotein
• membrane protein
• glycoprotein

Internet Database

UniProt: [1]

References

UniProt [2]

Fc receptor-like protein 6 (FcR-like protein 6, FcRL6, Fc receptor homolog 6, FcRH6, IFGP6, FCRL6, FCRH6)