Fatty Acid 2 Hydroxylase
From Anvita Health Wiki
Contents |
Function
- required for alpha- hydroxylation of free fatty acids & the formation of alpha- hydroxylated sphingolipids
- role in myelination in the CNS & PNS, & for epidermal permeability barrier homeostasis
Structure
- histidine box domains may contain the active site &/or be involved in metal ion binding
- contains 1 cytochrome b5 heme-binding domain
Compartment
- endoplasmic reticulum membrane
Expression
- detected in differentiating cultured keratinocytes (at protein level)
- detected in epidermis & cultured keratinocytes
- highly expressed in brain & colon detected at lower levels in testis, prostate, pancreas & kidney
- up-regulated during keratinocyte differentiation
More General Terms
Internet Database
Prosite: [1]
Prosite: [2]
UniProt: [3]
References
UniProt [4]
