Factor V Deficiency

From Anvita Health Wiki

Contents 1 Etiology 2 Genetics 3 Clinical-manifestations 4 Laboratory 5 Management 6 More General Terms 7 Internet Database 8 References

Etiology

• inherited
• acquired inhibitor of factor V

• post partum
• treatment with a certain type of fibrin glue
• surgery
• autoimmune diseases

• certain cancers

Genetics

• associated with defects in coagulation factor V

Clinical-manifestations

• similar to hemophilia, except bleeding into joints is less common
• bleeding into the skin
• bleeding of the gums
• excessive bruising
• excessive menstrual bleeding
• epistaxis
• prolonged or excessive loss of blood with surgery or trauma
• umbilical stump bleeding

Laboratory

• factor V assay shows decreased activity
• thrombin time is normal
• partial thromboplastin time ( PTT) is prolonged
• prothrombin time is prolonged
• bleeding time (slightly prolonged in some people)

Management

• fresh frozen plasma for bleeding or after surgery

More General Terms

• coagulation factor deficiency

Internet Database

OMIM: 227400

References

1. OMIM [1]
2. Medline Plus: Factor V deficiency [2]

factor V deficiency (Owren parahemophilia)