Exemestane

From Anvita Health Wiki

Contents 1 Indications 2 Adverse-effects 3 Clinical-significance 4 More General Terms 5 Internet Database 6 References

Indications

• treatment of advanced breast cancer in postmenopausal women with disease progression despite tamoxifen therapy [3]
• prophylaxis for breast cancer in high-risk women ? [4]

Adverse-effects

• osteoporosis: increased bone loss [5]
  
• drug adverse effects of aromatase inhibitors

Clinical-significance

• Clinical trial:

• 4742 women who had received 2-3 years of tamoxifen tamoxifen vs exemestane for an additional 2-3 years disease-free survival 87% ( tamoxifen) vs 92% (exemestane) thromboembolic events less in exemestane group new cancers (non breast cancer) fewer in exemestane group no difference in mortality [2]

More General Terms

• aromatase inhibitor
• antineoplastic agent (chemotherapeutic agent)

Internet Database

PubChem: 60198

References

1. Kaiser Permanente Northern California Pharmacy update, 11/2000
2. Journal Watch 24(7):58, 2004 Coombes RC et al, N Engl J Med 350:1081, 2004 PMID: [1] Piccart-Gebbart MJ, N Engl J Med 350:1040, 2004
3. New Evidence Supports the Third-generation Aromatase Inhibitor Exemestane (Aromasin) for Primary Breast Cancer Prescriber's Letter 11(4):22 2004 Detail-Document#: [2] (subscription needed) [3]
4. Goss PE et al Exemestane for Breast-Cancer Prevention in Postmenopausal Women N Eng J Med June 4, 2011 <PubMed> PMID: [4] <Internet> [5]
5. Cheung AM et al Bone density and structure in healthy postmenopausal women treated with exemestane for the primary prevention of breast cancer: a nested substudy of the MAP.3 randomised controlled trial. Lancet Oncol. 2012 Feb 6. <PubMed> PMID: [6] <Internet> [7]
   - Cauley JA Bone loss associated with prevention of breast cancer Lancet Oncol. 2012 Feb 6. <PubMed> PMID: [8] <Internet> [9]

exemestane (Aromasin)