Everolimus

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Mechanism-of-action 4 More General Terms 5 Internet Database 6 References

Indications

• pharmaceutical agent used in drug-eluting stent
• chemotherapy for advanced kidney cancer

Dosage

• oral agent

Mechanism-of-action

• antiproliferative agent
• reduces intimal hyperplasia
• protein kinase inhibitor

More General Terms

• antineoplastic agent (chemotherapeutic agent)

Internet Database

PubChem: 6442177
PubChem: 23724849
PubChem: 23305274
PubChem: 16211121

References

1. Stone GW, Midei M, Newman W, Sanz M, Hermiller JB et al; SPIRIT III Investigators. Comparison of an everolimus-eluting stent and a paclitaxel- eluting stent in patients with coronary artery disease: a randomized trial. JAMA. 2008 Apr 23;299(16):1903-13. PMID: [1]
   - Patel MR, Holmes DR Jr. Next-generation drug-eluting stents: a spirited step forward or more of the same. JAMA. 2008 Apr 23;299(16):1952-3. No abstract available. PMID: [2]
2. Prescriber's Letter 17(2): 2010 New Drugs Approved by the FDA in 2009 Detail-Document#: [3] (subscription needed) [4]

everolimus (Afinitor)