Etodolac

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Pharmacokinetics 5 Adverse-effects 6 Drug-interactions 7 Mechanism-of-action 8 More General Terms 9 Internet Database 10 References

Introduction

• Tradename Lodine.

Indications

• temporary relief of minor aches, pains, fever & inflammation
• not as effective as other NSAIDs for rheumatoid arthritis

Dosage

• 200-400 mg PO TID/ QID, max 1200 mg/day

• Tabs: 200, 300, 400 mg.

Pharmacokinetics

• well absorbed, onset of action 30 min-1 hour
• volume of distribution L/kg
• highly protein bound
• elimination 1/2life is about 7 hours
  

• elimination via liver
• 1/2life = 3.3-11.3 hours

Adverse-effects

• GI distress
• GI bleeding
• nausea
• headache
• nephrotoxicity (by analogy to celecoxib & rofecoxib)
  
• drug adverse effects of NSAIDs

Drug-interactions

• corticosteroids

• increased clearance of salicylates
• in combination increase renal & GI toxicity

• etodolac may decrease antihypertensive effects of ACE inhibitors
• in combination with warfarin may increase bleeding time
• etodolac may increase methotrexate levels & toxicity
  
• drug interaction(s) of lithium carbonate with NSAIDs
• drug interaction(s) of NSAIDs with SSRIs
• drug interaction(s) of aspirin with NSAIDs
• drug interaction(s) of NSAIDs with beta blockers
• drug interaction(s) of NSAIDs with ARBs
• drug interaction(s) of NSAIDs with ACE inhibitors
• drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
• drug interaction(s) of NSAIDs, diuretics & ACE inhibitors
• drug interaction(s) of NSAIDs & loop diuretics
• drug interaction(s) of NSAIDs & aspirin

Mechanism-of-action

• non known, but presumed to inhibit cyclooxygenase

• some selectivity for inhibition of COX-2 [4]

• analgesic, antipyretic & anti-inflammatory

More General Terms

• non-steroidal anti-inflammatory agent (NSAID)

Internet Database

PubChem: 3308

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
3. Kaiser Permanente Northern California Regional Drug Formulary, 2000
4. Prescriber's Letter 12(3): 2005
5. Geriatric Dosage Handbook, 6th edition, Selma et al eds, Lexi-Comp, Cleveland, 2001

etodolac (Lodine)