Estramustine

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 Dosage 5 Adverse-effects 6 Test-interactions 7 More General Terms 8 Internet Database 9 References

Introduction

• Tradenames: Emcyt,

Indications

• palliative treatment of prostatic cancer

Contraindications

• active thrombophlebitis
• hypersensitivity to estramustine, estradiol or nitrogen mustard

Dosage

• Take on an empty stomach
• Avoid taking with milk
• Capsule: 140 mg

Adverse-effects

• common (> 10%)

• diarrhea, nausea, decreased libido, breast tenderness, breast enlargement, edema, dyspnea, mild increases in liver function tests

• less common (1-10%)

• leg cramps, anorexia, flatulence, leukopenia, lethargy, thrombophlebitis, myocardial infarction, pulmonary embolism, insomnia

• uncommon (< 1%)

• night sweats, pigment changes, hypercalcemia, tinnitus, hot flashes, depression, cardiac arrest

Test-interactions

• increases serum K+

More General Terms

• antineoplastic agent (chemotherapeutic agent)

Internet Database

PubChem: 18140
PubChem: 259331
PubChem: 3268
PubChem: 40291
PubChem: 444000
PubChem: 259329
PubChem: 396361

References

Kaiser Permanente Northern California Regional Drug  Formulary, 1998

estramustine (Emcyt)