Erythroderma

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Contents 1 More Specific Terms 2 Introduction 3 Etiology 4 Clinical-manifestations 5 Laboratory 6 Management 7 More General Terms 8 Additional Terms 9 References

More Specific Terms

• congenital ichthyosiform erythroderma
• nonbullous congenital ichthyosiform erythroderma 1

Introduction

• Intense widespread (> 90%) reddening of the skin from dilated blood vessels, often associated with exfoliation.

Etiology

• primary cutaneous disorders

• psoriasis
• dermatitis

• atopic dermatitis
• stasis dermatitis
• contact dermatitis
• seborrheic dermatitis

• pityriasis rubra pilaris

• drug reactions ( hypersensitivity)

• barbiturates
• gold salts
• penicillins
• phenylbutazone
• quinine
• salicylates
• sulfonamides

• systemic disease

• lymphoma

• cutaneous T-cell lymphoma

• necrolytic migratory erythema

• idiopathic (47%)

Clinical-manifestations

• widespread erythema from dilated blood vessels (> 90% of body surface)
• may be associated scale, erosions, pustules, exfoliation, shedding of hair & nails
• potential systemic manifestations

• fever/ chills
• hypothermia
• reactive lymphadenopathy (50%)
• peripheral edema
• high-output cardiac failure

Laboratory

• complete blood count

• eosinophilia ( atopic dermatitis, hypersensitivity)
• atypical lymphocytosis ( hypersensitivity)

• peripheral blood smear:

• Sezary cell in cutaneous T-cell lymphoma

• serum chemistries

• abnormal liver function tests ( hypersensitivity)
• renal function tests ( hypersensitivity)

• serum IgE elelvations favors atopic dermatitis
• lymph node biopsy for suspected lymphoma
• skin biopsy confirms psoriasis

Management

• depends on etiology

More General Terms

• sign/symptom
• dermatitis

Additional Terms

• exfoliation (desquamation)

References

1. Stedman's Medical Dictionary, 26th ed. Williams & Wilkins
2. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 291
3. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009

erythoderma (exfoliative dermatitis)