Er Degradation Enhancing Alpha Mannosidase Like 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Additional Terms 6 Internet Database 7 References

Function

• extracts misfolded glycoproteins from calnexin cycle
• role in endoplasmic reticulum-associated degradation of glycoprotein
• targets misfolded glycoproteins for degradation ( N-glycan- dependent)
• lacks mannosidase activity
• interacts with DERL2 & DERL3

Structure

• belongs to the glycosyl hydrolase 47 family

Compartment

• edoplasmic reticulum membrane

More General Terms

• membrane protein
• glycoprotein

Additional Terms

• ER degradation-enhancing alpha-mannosidase-like

Internet Database

OMIM: 607673
UniProt: [1]

References

UniProt [2]

ER degradation-enhancing alpha-mannosidase-like 1 (EDEM1, EDEM, KIAA0212)