Epidermal Growth Factor Receptor Substrate 15 Like 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Internet Database 6 References

Function

• constitutive component of clathrin-coated pits
• required for receptor-mediated endocytosis
• interacts with EPS15, HRB & HRBL
• associates with clathrin-associated adapter protein complex 2 ( AP-2)
• phosphorylated on Tyr by EGFR

Structure

• contains 1 EF-hand domain
• contains 3 EH domains

Compartment

• cell membrane, nucleus
• localized to plasma membrane coated pits

More General Terms

• phosphoprotein
• membrane protein
• Ca+2 binding protein

Internet Database

Prosite: [1]
Prosite: [2]
UniProt: [3]

References

UniProt [4]

epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein, Eps15R, EPS15L1, EPS15R)