Endoplasmic Reticulum Aminopeptidase 2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 Pathology 7 More General Terms 8 Additional Terms 9 Internet Database 10 References

Function

• aminopeptidase
• role in peptide trimming
• preferentially hydrolyzes the basic residues Arg & Lys heterodimer; with ERAP1

• Cofactor: binds 1 Zn+2 per subunit ( putative)

Structure

• N-glycosylated
• belongs to the peptidase M1 family

Compartment

• endoplasmic reticulum membrane

Alternative-splicing

• named isoforms=4

Expression

• ubiquitously expressed
• highly expressed in spleen & leukocytes
• induced by IFN-gamma

Pathology

• defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance

More General Terms

• aminopeptidase
• glycoprotein
• membrane protein

Additional Terms

• endoplasmic reticulum aminopeptidase (ERAP)

Internet Database

Prosite: [1]
UniProt: [2]

References

UniProt [3]

endoplasmic reticulum aminopeptidase 2 (leukocyte-derived arginine aminopeptidase, L-RAP, ERAP2, LRAP)