Elastin

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Function 3 Structure 4 Compartment 5 Expression 6 More General Terms 7 Additional Terms 8 Internet Database 9 References

More Specific Terms

• tropoelastin

Function

• elastic protein in connective tissue
• allows many tissues in the body to resume their shape after stretching or contracting
• helps skin to return to its original position when displaced
• role in load-bearing tissue where mechanical energy is stored ( tendons)
• forms a ternary complex with BGN & MFAP2
• interacts with MFAP2 via divalent cations (Ca+2 > Mg+2 > Mn+2) dose-dependent & saturatable

Structure

• primarily composed of Gly, Val, Ala, & Pro
• made by linking many soluble tropoelastins, in a reaction catalyzed by lysyl oxidase, to make a massive insoluble, durable cross-linked array
• cross-linking is via Lys
• most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, & isodesmosine
• hydroxylation on proline residues within the sequence motif, GXPG

Compartment

• extracellular matrix

Expression

• arteries, especially large elastic blood vessels ( aorta)
• lungs, elastic ligaments, skin, bladder, & elastic cartilage

More General Terms

• matrix protein

Additional Terms

• elastase
• elastin receptor (ELNR1)

Internet Database

UniProt: [1]
OMIM: 130160

References

1. Wikipedia - elastin entry [2]
2. UniProt [3]

elastin (ELN)