Early Onset Hypertension With Severe Exacerbation In Pregnancy

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Contents 1 Pathology 2 Genetics 3 Clinical-manifestations 4 More General Terms 5 Internet Database 6 References

Pathology

• suppression of aldosterone secretion
• mutant form of receptor is associated with activation by progesterone [2]

Genetics

• autosomal dominant
• associated with defects in NR3C2 are a cause of

Clinical-manifestations

• onset of severe hypertension before the age of 20
• severe exacerbation of hypertension in pregnant women

More General Terms

• endocrine disease

Internet Database

OMIM: 605115

References

1. OMIM [1]
2. Geller DS et al Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science 289:119, 2000 PMID: &dopt=Abstract

early onset hypertension with severe exacerbation in pregnancy