E3 Ubiquitin Protein Ligase Rnf5

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• E2-dependent E3 ubiquitin-protein ligase activity
• may function together with E2 ubiquitin-conjugating enzymes UBE2D1/ UBCH5A & UBE2D2/ UBC4
• mediates ubiquitination of PXN/ paxillin
• may be involved in regulation of cell motility & localization of PXN/ paxillin
• interacts with PXN

Structure

• contains 1 RING-type zinc finger

Compartment

• membrane, plasma membrane (majority)
• cytoplasmic organelles

Expression

• widely expressed

Pathology

• interacts with Salmonella typhimurium sopA

• mediates ubiquitination of sopA

More General Terms

• E3 ubiquitin ligase
• ring finger protein
• membrane protein

Internet Database

OMIM: 602677
Prosite: [1]
Prosite: [2]
UniProt: [3]

References

UniProt [4]

E3 ubiquitin-protein ligase RNF5 (HsRma1, RING finger protein 5, protein G16, RNF5, G16, NG2, RMA1)