E3 Ubiquitin Protein Ligase March11

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 More General Terms 6 Internet Database 7 References

Function

• E3 ubiquitin-protein ligase
• mediates polyubiquitination of CD4
• may play a role in ubiquitin-dependent protein sorting in develomenting spermatids ( putative)
• interacts (via YXXL motif) with AP1M1
• interacts (via PDZ-binding motif) with LIN7A
• interacts with unidentified fucose glycoproteins ( putative)
• protein modification; protein ubiquitination

Structure

• the RING-CH-type Zn+2 finger domain is required for E3 ligase activity ( putative)
• contains 1 RING-CH-type Zn+2 finger

Compartment

• cytoplasmic vesicle membrane

Alternative-splicing

• named isoforms=2

More General Terms

• E3 ubiquitin ligase
• zinc finger protein
• membrane protein

Internet Database

UniProt: [1]

References

UniProt [2]

E3 ubiquitin-protein ligase MARCH11 (membrane-associated RING finger protein 11, MARCH-XI, MARCH11)