E3 Ubiquitin Protein Ligase March1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Alternative-splicing 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• E3 ubiquitin-protein ligase
• ubiquitin conjugation, 3rd step
• may mediate ubiquitination of TFRC, CD86 & FAS, & promote their subsequent endocytosis & sorting to lysosomes via multivesicular bodies

Structure

• contains 1 RING-CH-type zinc finger, required for E3 ligase activity Compatment: cytoplasmic vesicle membrane

Alternative-splicing

• named isoforms=2

Expression

• expressed in lymph nodes, spleen & lung

More General Terms

• E3 ubiquitin ligase
• ring finger protein
• membrane protein

Internet Database

UniProt: [1]

References

UniProt [2]

E3 ubiquitin-protein ligase MARCH1 (membrane-associated RING finger protein 1, membrane-associated RING-CH protein 1, MARCH-1, RING finger protein 171, MARCH1, RNF171)