Dynein Heavy Chain

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Function 3 Structure 4 Compartment 5 More General Terms 6 Additional Terms 7 References

More Specific Terms

• ciliary dynein heavy chain 5 (axonemal beta dynein heavy chain 5, HL1, DNAH5, DNAHC5, KIAA1603)
• ciliary dynein heavy chain 8 (axonemal beta dynein heavy chain 8, DNAH8)
• cytoplasmic dynein 2 heavy chain 1; cytoplasmic dynein 2 heavy chain; dynein cytoplasmic heavy chain 2; dynein heavy chain isotype 1B; dynein heavy chain 11; hDHC11 (DYNC2H1, DHC1B, DHC2, DNCH2, DYH1B, KIAA1997)
• dynein cytoplasmic heavy chain 1 (DYNC1H1, DHC1, DNCH1, DNCL, DNECL, DYHC, KIAA0325)
• dynein heavy chain 1, axonemal (ciliary dynein heavy chain 1, axonemal beta dynein heavy chain 1, heat shock regulated protein 1, XLHSRF-1, hDHC7, DNAH1, DHC7, DNAHC1, KIAA1410)
• dynein heavy chain 10, axonemal (ciliary dynein heavy chain 10, axonemal beta dynein heavy chain 10, DNAH10, KIAA2017)
• dynein heavy chain 11; ciliary dynein heavy chain 11; axonemal dynein heavy chain 11 (DNAH11)
• dynein heavy chain 17, axonemal (ciliary dynein heavy chain 17, axonemal beta dynein heavy chain 17, ciliary dynein heavy chain-like protein 1, axonemal dynein heavy chain-like protein 1, dynein light chain 2, axonemal, DNAH17, DNAHL1, DNEL2)
• dynein heavy chain 2, axonemal (ciliary dynein heavy chain 2, axonemal beta dynein heavy chain 2, dynein heavy chain domain-containing protein 3, DNAH2, DNAHC2, DNHD3, KIAA1503)
• dynein heavy chain 3, axonemal (ciliary dynein heavy chain 3, axonemal beta dynein heavy chain 3, HsADHC3, Dnahc3-b, DNAH3, DNAHC3B)
• dynein heavy chain 6, axonemal (DNAH6, DNAHC6, HL2, KIAA1697)
• dynein heavy chain 7, axonemal (ciliary dynein heavy chain 7, dynein heavy chain-like protein 2, HDHC2, DNAH7, KIAA0944)
• dynein heavy chain 9 (ciliary dynein heavy chain 9, axonemal dynein heavy chain 9, DNAH9, dynein axonemal heavy chain 17-like, DNAH17L, dynein axonemal light intermediate chain 1, DNEL1)

Function

• catalytic subunit of dynein

Structure

• dynein heavy chains probably consist of an N-terminal stem (which binds cargo & interacts with other dynein components), & the head or motor domain
• the motor contains 6 tandemly-linked AAA domains in the head, which form a ring
• a stalk-like structure (formed by 2 coiled coil domains) protrudes between AAA 4 & AAA 5 & terminates in a microtubule- binding site
• a 7th domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain
• 4 well- conserved & 2 non- conserved ATPase sites, one per AAA domain
• probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function

Compartment

• cytoplasm

More General Terms

• enzyme catalytic subunit
• adenosine triphosphatase (ATPase)

Additional Terms

• dynein

References

UniProt [1]

dynein heavy chain