Dynein

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Function 3 Structure 4 More General Terms 5 Internet Database 6 References

More Specific Terms

• cytoplasmic dynein complex 2

Function

• cytoplasmic dynein directs minus-end or retrograde transport of vesicles along microtubules, whereas kinesin directs plus-end or anterograde movement
• dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP
• ciliary dynein is the force generating protein of respiratory cilia
• ciliary dynein is required for structural & functional integrity of cilia of ependymal cells lining the brain ventricles

Structure

• molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides & a number of intermediate chains & light chains
• [4] depicts 2 light chains

More General Terms

• adenosine triphosphatase (ATPase)
• microtubule-associated protein (MAP)
• multisubunit protein

Internet Database

OMIM: 600112

References

1. Stryer Biochemistry WH Freeman & Co, New York, 1988 pg 942
2. Kumar J, Yu H, Sheetz MP. Kinectin, an essential anchor for kinesin-driven vesicle motility. Science. 1995 Mar 24;267(5205):1834-7. PMID: [1]
3. OMIM [2]
4. Adams JM, Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci. 2001 Jan;26(1):61-6. Review. PMID: [3]

dynein