Dry Earwax Phenotype

From Anvita Health Wiki

Contents 1 Introduction 2 Epidemiology 3 Genetics 4 More General Terms 5 Additional Terms 6 Internet Database 7 References

Introduction

• Human earwax is a mendelian trait consisting of wet & dry types. The wet earwax is brownish and sticky, whereas the dry type lacks cerumen.

Epidemiology

• frequently (80-95%) among East Asians
• uncommon (0-3%) in populations of European or African origin
• Intermediate frequencies (30-50%) of the dry type in populations

• Southern Asia
• Pacific Islands
• Central Asia
• Asia Minor
• Native North American
• Inuit of Asian ancestry

Genetics

• allele with Arg-184 in the ABCC11 gene is responsible for the dry earwax phenotype.
• autosomal recessive

• Intermediate frequencies (30-50%) of the dry type are seen in populations of Southern Asia, the Pacific Islands, Central Asia & Asia Minor, as well as among the Native North American & Inuit of Asian ancestry.

More General Terms

• genetic disease of the exocrine function
• otorhinolaryngologic disease; ear, nose & throat (ENT) disease

Additional Terms

• ATP-binding cassette transporter sub-family C member 11; multidrug resistance-associated protein 8 (ABCC11, MRP8)
• cerumen

Internet Database

OMIM: 605990

References

1. UniProt [1]
2. OMIM [2]

dry earwax phenotype