Drug Interaction Non Steroidal Anti Inflammatory Agent Serotonin Reuptake Inhibitor

From Anvita Health Wiki

Drug-interactions

• risk of GI bleed, conflicting data

• SSRI used concurrently with NSAIDs increases risk of GI-bleeding 12-fold [1]
• combining an NSAID with an SSRI did not further elevate the risk of GI bleeding [2]

More General Terms

• drug interaction

References

1. Prescriber's Letter 12(7): 2005 Selective Serotonin Reuptake Inhibitors (SSRIs) and Antiplatelet Activity Detail-Document#: [1] (subscription needed) [2]
2. Targownik LE et al Selective serotonin reuptake inhibitors are associated with a modest increase in the risk of upper gastrointestinal bleeding. Am J Gastroenterol 2009 Jun; 104:1475. PMID: [3]

drug interaction(s) of NSAIDs with SSRIs