Drug Interaction Ace Inhibitor Angiotensin Ii Receptor Antagonist

From Anvita Health Wiki

Contents 1 Drug-interactions 2 Management 3 More General Terms 4 References

Drug-interactions

• ARBs potentiate adverse effects of ACE inhibitors: [1]

• symptomatic hypotension
• renal failure
• hyperkalemia

• combining ACE inhibitor with ARB does not improve outcomes [2]
• combination results in small increase in risk of cancer (14%) [3]

Management

• ARB as effective as ACE inhibitor in management of patients at high risk for cardiovascular events [2]

More General Terms

• drug interaction

References

1. Phillips CO, Kashani A, Ko DK, Francis G, Krumholz HM. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from randomized clinical trials. Arch Intern Med. 2007 Oct 8;167(18):1930-6. Review. PMID: [1]
2. Yusuf S et al for the ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008, 358:1547 PMID: [2]
3. Bangalore S et al Antihypertensive drugs and risk of cancer: network meta- analyses and trial sequential analyses of 324 168 participants from randomised trials The Lancet Oncology, Early Online Publication, 30 November 2010 <PubMed> PMID: [3] <Internet> [4]
4. National Guideline Clearinghouse ACE inhibitor and angiotensin II antagonist combination treatment. Caring for Australasians with Renal Impairment ngc-guideline: [5]

drug interaction(s) of ACE inhibitors with angiotensin II receptor antagonists